Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia

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Failure to Use Corollary Discharge to Remap Visual Target Locations Is Associated with Psychotic Symptom Severity in Schizophrenia 2 3

1 Department of Psychiatry, University Medical Center 3584 CX Utrecht, the Netherlands 7 2 Bernstein Center for Computational Neuroscience & Department of Psychology, Humboldt 8 Universität, 10099 Berlin, Germany 9 3 Department of Experimental Psychology, Helmholtz Institute, Utrecht University, 3584 CX 10 Utrecht, The Netherlands 11 4 Department of Psychiatry, Psychosomatic Medicine and Psycho...

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Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia.

Corollary discharge (CD) refers to "copies" of motor signals sent to sensory areas, allowing prediction of future sensory states. They enable the putative mechanisms supporting the distinction between self-generated and externally generated sensations. Accordingly, many authors have suggested that disturbed CD engenders psychotic symptoms of schizophrenia, which are characterized by agency dist...

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Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations.

CONTEXT A forward model of intended thoughts and actions prepares sensory cortex for sensations that are a consequence of those actions. Imprecision of the corollary discharge in schizophrenia may contribute to the misperception of inner experiences and thoughts as "voices" or auditory hallucinations. OBJECTIVES To assess the precision of the forward model in schizophrenia using the N100 comp...

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Disrupted Saccadic Corollary Discharge in Schizophrenia.

UNLABELLED Disruptions in corollary discharge (CD), motor signals that send information to sensory areas and allow for prediction of sensory states, are argued to underlie the perceived loss of agency in schizophrenia. Behavioral and neurophysiological evidence for CD in primates comes largely from the saccadic double-step task, which requires participants to make two visually triggered saccadi...

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Visual perception and corollary discharge.

Perception depends not only on sensory input but also on the state of the brain receiving that input. A classic example is perception of a stable visual world in spite of the saccadic eye movements that shift the images on the retina. A long-standing hypothesis is that the brain compensates for the disruption of visual input by using advance knowledge of the impending saccade, an internally gen...

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ژورنال

عنوان ژورنال: Journal of Neurophysiology

سال: 2015

ISSN: 0022-3077,1522-1598

DOI: 10.1152/jn.00155.2015